Aunt May. It’s really a miracle that she lived as long as she did. The woman was in her 70’s for about 30 years, always on the verge of death from some disease or another.
In 1995, writer J. M. DeMatteis agreed and finally killed her off in Amazing Spider-Man #400.
There were also a bunch of Spider-Clones running around. Don’t worry, we’ll talk about that. Of course we'll talk about that.
Next Time: She-Hulk (2004) #1-6 by Dan Slott